Methods of optimising binding assays are disclosed using binding agents having binding sites specific for an analyte by varying the density of binding sites on a solid phase, advantageously extending the working range of the assay and/or improving the precision of the assay within a given range....http://www.google.com.hk/patents/US5830762?utm_source=gb-gplus-share專利 US5830762 - Materials and methods relating to binding assays