A method is provided for generation of bone at a site of an animal where skeletal tissue is deficient comprising administering to the animal, locally at the bone site in the presence of a source of osteogenic cells, an effective amount of a composition comprising TGF-.beta. in a pharmaceutically acceptable...http://www.google.com.hk/patents/US5604204?utm_source=gb-gplus-share專利 US5604204 - Method of inducing bone growth using TGF-.beta.