PNU 282987 is a highly selective α7 nAChR agonist (Ki = 26 nM) displaying negligible blockade of α1β1γδ and α3β4 nAChRs (IC50 ≥ 60 μM). Found to be inactive ...

PNU-282987 is a potent α7 nicotinic acetylcholine receptor (nAChR) agonist with an EC50 of 154 nM. PNU-282987 is also a functional antagonist of the 5-HT3 ...

PNU-282,987 is a drug that acts as a potent and selective agonist for the α7 subtype of neural nicotinic acetylcholine receptors.

Sep 4, 2022 · ... 282987 (1 mg/ml) for 5 days. The PNU mock control group was given sterile water, and on the fourth day, PNU-282987 (1 mg/ml) was ...

A, [Ca2+]i signal induced by increasing concentrations of the selective α7-nAChR agonist, PNU 282987 (1 nM–10 μM), in the absence or presence of PNU 120596 (0.5 ...

PNU-282987 is a potent and selective a7 nAChR agonist. This compound showed high affinity for the rat a7 nAChR (Ki = 26 nM) and activity at the a7–5-HT3 ...

Jan 12, 2013 · 6) was used as a measure of anxiety in Sprague-Dawley rats. PNU-120596 (1 mg/kg or 10 mg/kg) and PNU-282987 (1 mg/kg) did not significantly ...

PNU-282987 (1 mg/kg/d) and MLA (3 mg/kg/d) were solubilized in saline and intraperitoneally injected for consecutive 14 days after the DAI establishment.

Mar 1, 2005 · In contrast, administration of PNU-282987 (1 mg/kg i.v.; n = 6) significantly restored auditory gating (Fig. 4B; determined from the average of ...

Mar 12, 2019 · In contrast, inflammatory cell infiltration and edema were obviously attenuated in the lungs after treatment with PNU-282987 (1 mg/kg) both pre- ...