TH7755 demonstrates a greatly improved cellular target engagement and 6-thioguanine potentiation compared with TH1760, while showing no cytotoxicity on its own.
Mar 19, 2021 · TH7755 is a cell-active NUDT15 inhibitor as evidenced by thioguanine potentiation.A, cell viability testing of TH7755 in AML HL-60 cells, ...
Mar 24, 2021 · Building upon this, we herein report the development of the potent and specific NUDT15 inhibitor, TH7755. TH7755 demonstrates a greatly ...
The development of TH7755 inhibitor from this research was a breakthrough. TH7755 made it possible to obtain well-diffracting crystals of NUDT15 mutants and ...
Structure of NUDT15 V18I Mutant in complex with TH7755 ; Functional Keywords, inhibitor, complex, nucleoside triphosphate pyrophosphohydrolase, hydrolase.
Structure of NUDT15 R139H Mutant in complex with TH7755 ; Biological source, Homo sapiens (Human) ; Total number of polymer chains, 4 ; Total formula weight ...
TH7755 demonstrates a greatly improved cellular target engagement and. 6-thioguanine potentiation compared with TH1760, while showing no cytotoxicity on its own ...
TH7755 demonstrates a greatly improved cellular target engagement and 6-thioguanine potentiation compared to TH1760, while showing no cytotoxicity on its own.
Aug 10, 2021 · TH7755 demonstrates a greatly improved cellular target engagement and 6-thioguanine potentiation compared with TH1760, while showing no ...