Inhibition of tissue-nonspecific alkaline phosphatase (TNAP) may prevent ectopic soft tissue calcification by increasing endogenous pyrophosphate (PPi).
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Controller circuitry with monitoring and logic functions to make CMOS RAM nonvolatile; Controls up to 8 memories; Monitors Vcc and write-protects when out ...
Nov 18, 2022 · This study evaluated the anticalcification effects of DS-1211, an orally administered, potent, and highly selective small molecule TNAP ...
Dec 1, 2022 · A Phase 2 clinical trial has started of DS-1211 in individuals with pseudoxanthoma elasticum (PXE), a rare multisystem genetic disease that ...
May 31, 2023 · DS-1211 is a potent and selective novel small molecule tissue-nonspecific alkaline phosphatase (TNAP) inhibitor.
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The DS1211 Nonvolatile Controller x 8 Chip is a CMOS circuit which solves the application problem of converting CMOS RAMs into nonvolatile memories ...
Jan 12, 2022 · DS-1211 is a potent and specific small-molecule inhibitor of TNAP. In vitro and in vivo animal studies have shown that it is effective in ...
DS-1211 is a potent and selective novel small molecule TNAP inhibitor with well-characterized pharmacokinetics (PKs) in rodent and monkey. Herein, we report a ...
Sep 7, 2017 · DS-1211 is a first-in-class small molecule jointly developed through a research collaboration between Daiichi Sankyo and SBP, which resulted ...